The purpose of this research was to study mucoadhesive bilayer tablets of Cefuroxime Axetil (CA) using the mucoadhesive polymers HPMC and Carbopol 934P along with ethyl cellulose as an impermeable nonmucoadhesive backing layer. CA incorporated in the adhesive layer of the tablet, which comes in contact with the mucosal surface of intestine. In addition to achieve unidirectional release toward the mucosa, ethyl cellulose used as a backing layer. Eudragit L100 was used as enteric coating material. Eudragit L100 coated tablet release the drug only at higher pH. Response surface designs were adequately applied to study the effect of different formulation variables on the release profile and mucoadhesive strength to select optimized formulation. Results indicate that release profile and mucoadhesion properties of tablets can be controlled by changing the polymer type and concentration.
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